Study 01

Safety and Tolerability Trial

Study 02

Pilot Dose-Finding PD/PK Trial

Study 03

Kava-Kratom Blend Safety

Study 04

Itraconazole Interaction PK

Study 05

Single and Multiple Dose PK

Study 06

Drug Interaction Potential

Study 07

Healthy Adult PK Assessment

Study 08

Cardiovascular Case Series

Study 09

ECG Abnormalities Study

Study 10

Pain Tolerance Trial

Study 11

Psychotic Symptoms Prevalence

Study 12

Long-Term Cognitive Effects

Study 13

Brain MRI Study

Study 14

Psychological Withdrawal Severity

Study 15

Hormone Levels Study

Study 16

Hematology and Clinical Chemistry

Study 17

Mitragynine PK in Man

Study 18

Dependence, Withdrawal and Craving